Forschung - Pankreaszentrum

Durch patientenorientierte klinische Studien und Grundlagenforschung können Pankreastumore erforscht und die Behandlung stetig verbessert werden.

Am Pankreaszentrum Marburg wird ausgiebig in nationalen und internationalen Forschungsverbünden zu endokrinen und exokrinen Pankreastumoren geforscht.

Viele Forschungsvorhaben werden aufgrund ihrer hohen Qualität z.B. durch die Deutsche Forschungsgemeinschaft (DFG), die EU und die Deutsche Krebshilfe gefördert.

Zudem steht unserem Forschungslabor ein transgenes Tumormausmodell zu Verfügung, das erstmalig die Entstehung des humanen Pankreaskarzinoms widerspiegelt.


Einen Überblick gibt die Auflistung der wichtigsten Publikationen aus den letzten Jahren:

Early endocrine neoplasia of the pancreas
Fendrich V, Bartsch DK.
Chirurg, 89:266-273 (2018)

Prognosis of sporadic resected small (≥2cm) nonfunctional pancreatic neuroendocrine tumors – a multi-institutional study
Sallinen VJ, Le Large TYS, Tieftrunk E, Galeev S, Kovalenko Z, Haugvik SP, Antila A, Franklin O, Mantinez-Moneo E, Robinson SM, Panzuto F, Regenet N, Muffatti F, Partelli S, Wiese D, Rusziewski P, Dousset B, Edwin B, Bartsch DK,
Sauvanet A, Falconi M, Ceyhan GO, Gaujoux S.
HPB (Oxford), 20:251-259 (2018)

Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: Systematic review and meta-analysis.
Mintziras I, Miligkos M, Wächter S, Manoharan J, Maurer E, Bartsch DK
Int J Surg, 59:19-26 (2018)

Expression of neuropeptide Y and its receptors Y1 and Y2 in pancreatic intraepithelial neoplasia and invasive pancreatic cancer in a transgenic mouse model and human samples of pancreatic cancer.
Waldmann J, Fendrich V, Reichert M, Hecker A, Bartsch DK, Padberg W, Holler JPN.
J Surg Res, 223:230-236 (2018).

Preoperative imaging overestimates the tumor size in pancreatic neuroendocrine neoplasms associated with multiple endocrine neoplasia Type 1.
Polenta V, Slater EP, Kann PH, Albers MB, Manoharan J, Ramaswamy A, Mahnken AH, Bartsch DK.  
World J Surg, 42:1440-1447 (2018)

Implementation of current ENETS guidelines for surgery of small (≤2cm) pancreatic neuroendocrine neoplasms in the German surgical community: An analysis of the prospective DGAV.
Mintziras I, Keck T, Werner J, Fichtner-Feigl S, Wittel U, Senninger N, Vowinkel T, Köninger J, Anthuber M, Geißler B, Bartsch DK
World J Surg, Epub ahead of print (2018)

Pharmocological inhibition of class IIA HDACs by LMK-235 in pancreatic neuroendocrine tumor cells.
Wanek J, Gaisberger M, Beyreis M, Mayr C, Helm K, Primavesi F, Jäger T, Di Fazio P, Jakab M, Wagner A, Neureiter D, Kiesslich T.
Int J Mol Sci, 19:3128-3141 (2018)

German National Case Collection for familial pancreatic Cancer (FaPaCa) - acceptance and psychological aspects of a pancreatic cancer screening program.
Franke FS, Matthäi E, Slater EP, Schicker C, Kruse J, Bartsch DK.
Hereditary Cancer in Clinical Practice, 16:17-25 (2018)

Surgical strategies for small sporadic neuroendocrine pancreatic tumors
Holzer K  
Chirurg, 89:422-427 (2018)

HDAC-linked „Proliferative“ miRNA expression pattern in pancreatic neuroendocrine tumors.
Klieser E, Urbas R, Swierczynski S, Stättner S, Primavesi F, Jäger T, Mayr C, Kiesslich T, Di Fazio P, Helm K, Neureiter D.
Int J Mol Sci, 19:2781 (2018)

Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.  
Fendrich V, Jendryschek F, Beeck S, Albers MB, Lauth M, Esni F, Heeger K, Dengler J, Slater EP, Holler JPN, Baier A, Bartsch DK, Waldmann J.  
Oncogene, 37:1845-1856 (2018)

European evidence-based guidelines on pancreatic cystic neoplasms.
The European Study Group on Cystic Tumours of the Pancreas. Marco Del Chiaro, Marc G Besselink, Lianne Scholten, Marco J Bruno, Djuna L Cahen, Thomas M Gress, Jeanin E van Hooft, Markus M, Lerch, Julia Mayerle, Thilo Hackert, SoheiSatoi,Alessandro Zerbi, David Cunningham, Claudio De Angelis, Marc Giovannini, Enrique de-Madaria, Peter Hegyi, Jonas Rosendahl, Helmut Friess, Riccardo Manfredi, Philippe Lévy, Francisco X Real, Alain Sauvanet, Mohammed Abu Hilal, Giovanni Marchegiani, Irene Esposito, Paula Ghaneh, Marc RW Engelbrecht, Paul Fockens, Nadine CM van Huijgevoort, Christopher Wolfgang, Claudio Bassi, Natalya B Gubergrits, Caroline Verbeke, Günter Klöppel, Aldo Scarpa, Giuseppe Zamboni, Anne Marie Lennon, Malin Sund, Nikolaos Kartalis, Lars Grenacher, Massimo Falconi, Urban Arnelo, Kostantin V Kopchak, Kofi Oppong, Colin McKay, Truls Hauge, Kevin Conlon, Mustapha Adham, Güralp O Ceyhan, Roberto Salvia, Christos Dervenis, Peter Allen, François Paye, Detlef K Bartsch, Matthias Löhr,Massimiliano Mutignani, Johanna Laukkarinen, Richard Schulick, Roberto Valente,Thomas Seufferlein, Gabriele Capurso, Ajith Siriwardena,
John P Neoptolemos, Aldis Pukitis, Ralf Segersvärd, A Aghdassi, S Andrianello, P Bossuyt, R Bülow, K Cárdenas-Jaén, P Cortegoso, M Fontana, L Haeberle, M Heckler, A Litvin, K Mann, C Michalski,P Michl, G Nappo, G Perri, S Persson, F Scheufele, F Sclafani,
M Schmidt, L Venezia, F Volker, M-P Vullierm, and L Wüsten.
Gut, 67:789-804 (2018)

Induktion des Autophagie-assoziierten Zelltodes durch Histon-Deacetylase Inhibition in pankreatischen neuroendokrinen Tumorzellsphäroiden.
Matrood S, Wissniowski TT, Wiese D, Griesmann H, Egidi M, Wanzel M, Stiewe T, Buchholz M, Gress T,
Bartsch DK, Di Fazio P
Zeitschrift für Gastroenterologie, 56:e234 (2018)

The indications for laparoscopic pancreatectomy.  
Siech M, Strauss P, Huschitt S, Bartsch DK, Wittel U, Keck T.  
Dtsch Arztebl Int. 114:263-268 (2017)  

StuDoQ Pancreas study group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV). Laparoscopic versusopen distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.
Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K, Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T
Int J Colorectal Dis, 32:273-280 (2017)

Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors -
a multi-institutional study.
Sallinen VJ, Le Large TTY, Tieftrunk E, Galeev S, Kovalenko Z, Haugvik SP, Antila A, Franklin O, Martinez-Moneo E, Robinson SM, Panzuto F, Regenet N, Muffatti F, Partelli S, Wiese D, Ruszniewski P, Dousset B, Edwin B, Bartsch DK, Sauvanet A, Massimo F, Ceyhan GO, Gaujoux S
The Official Journal of the International Hepato Pancreato Biliary Association 1-9, (2017)

Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor
Goehringer C, Sutter C, Kloor M, Gebert J, Slater EP, Keller M, Treiber I, Ganschow P, Kadmon M, Moog U.  
Familial Cancer, 16:303-309 (2017)

Preoperative imaging overestimates the tumor size in pancreatic neuroendocrine neoplasms associated with multiple endocrine neoplasia type 1.
Polenta V, Slater EP, Kann PH, Albers MB, Manoharan J, Ramaswamy A, Mahnken AH, Bartsch DK
World J Surg. Epub, first online Oct 26 (2017)  

Systematic review of active surveillance versus surgical management of asymptomatic small non-functioning pancreatic neuroendocrine neoplasms   
Partelli S, Cirocchi R, Crippa S, Cardinali L, Fend
rich V, Bartsch DK, Falconi M.
Br J Surg, 104:34-41 (2017)

ENETS consensus guidelines for standard of care in neuroendocrine tumours: surgery for small intestinal and pancreatic neuroendocrine tumours.
Partelli S, Bartsch DK, Capdevila J, Chen J, Knigge U, Niederle B, Nieveen van Dijkum EJM, Pape UF, Pascher A, Ramage J, Reed N, R
uszniewski P, Scoazec
JY, Toumpanakis C, Kianmanesh R, Falconi M;
Neuroendocrinology, 2017;105:255-265 (2017)  

ENETS Consensus recommendations for the standards of care in neuroendocrine neoplasms: Follow-Up and documentation.
Knigge U, Capdevila J, Bartsch DK, Baudin E, Falkerby J, Kianmanesh R, Kos-Kudla B, Niederle B, Nieveen van Dijkum E, O'Toole D, Pascher A, Reed N,
Sundin A, Vullierme MP  
Neuroendocrinology 105:310-319 (2017)  

Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome
Klieser E, Urbas R, Stättner S, Primavesi F, Jäger T, Dinnewitzer A, Mayr C,
Kiesslich T, Holzmann K, Di Fazio P, Neureiter D, Swierczynski S.
Hum Pathol; 65:41-52 (2017)

Early endocrine neoplasia of the pancreas.  
Fendrich V, Bartsch DK  
Chirurg, Epub Nov 2 (2017)

Surgical therapy of sporadic pancreatic neuroendocrine neoplasias G1/G2.  
Fendrich V, Bartsch DK  
Visc Med, 33:344-350 (2017)

Robotic-assisted approach improves vessel preservation in spleen-preserving distal pancreatectomy.
Eckhardt S, Schicker C, Maurer E, Fendrich V, Bartsch DK.
Dig Surg. 33:406-13 (2016)

C-reactive protein as a new prognostic factor for survival in patients with pancreatic neuroendocrine neoplasia.
Wiese D, Kampe K, Waldmann J, Heverhagen AE, Bartsch DK, Fendrich V.
J Clin Endocrinol Metab, 101:937-44 (2016)

ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors.
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M,
Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference participants.
Neuroendocrinology 103:153-71 (2016)

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.
Calabretta S, Bielli P, Passacantilli I, Pilozzi E, Fendrich V, Capurso G, Fave GD, Sette C.
Oncogene 35:2031-9 (2016)

Refinement of screening for familial pancreatic cancer.
Bartsch DK, Slater EP, Carrato A, Ibrahim IS, Guillen-Ponce C, Vasen HF, Matthäi E, Earl J, Jendryschek FS, Figiel J, Steinkamp M, Ramaswamy A, Vázquez-Sequeiros E, Muñoz-Beltran M, Montans J, Mocci E, Bonsing BA, Wasser M, Klöppel G, Langer P, Fendrich V, Gress TM.
Gut 65:1314-21 (2016)

Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor.
Goehringer C, Sutter C, Kloor M, Gebert J, Slater EP, Keller M, Treiber I, Ganschow P, Kadmon M, Moog U.
Fam Cancer, Epub Nov 12 (2016)

Minimally invasive versus open pancreatic surgery in patients with multiple endocrine neoplasia type 1.
Lopez CL, Albers MB, Bollmann C, Manoharan J, Waldmann J, Fendrich V, Bartsch DK.
World J Surg; 40:1729-36.(2016)

The benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers.
Vasen H, Ibrahim I, Ponce CG, Slater EP, Matthäi E, Carrato A, Earl J, Robbers K, van Mil AM, Potjer T, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bergman W, Wasser M, Morreau H, Klöppel G, Schicker C, Steinkamp M, Figiel J,Esposito I, Mocci E, Vazquez-Sequeiros E, Sanjuanbenito A, Muñoz-Beltran M, Montans J, Langer P, Fendrich V, Bartsch DK.
J Clin Oncol, 34:2010-9 (2016)

Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.
Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K, Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T; StuDoQ
Pancreas study group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV).
Int J Colorectal Dis, Epub Nov 4 (2016)

Familial Pancreatic Cancer: To Screen or not to Screen.
Vasen HF, Bartsch DK
EBioMedicine 2:1858-1859 (2015)

Molecular Characterization and Pathogenesis of Intraductal Papillary Mucinous Neoplasms of the Pancreas.
Benzel J, Fendrich V.
Eur Surg Res 55: 352-363 (2015)

EndoplasmicReticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.
Klieser E, Illig R, Státtner S, Primavesi F, Jáger T, Swierczynski S, Kiesslich T,
Kemmerling R, Bollmann C, Di Fazio P, Neureiter D.
Anticancer Res 35:6127-6136 (2015)

Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.
Lichtenauer UD, Di Dalmazi G, Slater EP, Wieland T, Kuebart A, Schmittfull
A, Schwarzmayr T, Diener S, Wiese D, Thasler WE, Reincke M, Meitinger T,
Schott M, Fassnacht M, Bartsch DK, Strom TM, Beuschlein F.
J Clin Endocrinol Metab 100:E776-782. (2015)

Long-Term Outcomes of Surgical Management of Pancreatic Neuroendocrine Tumors with Synchronous Liver Metastases.
Partelli S, Inama M, Rinke A, Begum N, Valente R, Fendrich V, Tamburrino D
Keck T, Caplin ME, Bartsch DK, Thirlwell C, Fusai G, Falconi M.
Neuroendocrinology 102:68-76 (2015)

Limited resection of pancreatic cancer in high-risk patients can result in a
secondprimary.
Potjer TP, Bartsch DK, Slater EP, Matthäi E, Bonsing BA, Vasen HF.
Gut 64:1342-1344 (2015)

LCN2 and TIMP1 as potential serum markers for the early detection of familial pancreatic cancer
Slater EP, Fendrich V, Strauch K, Rospleszcz S, Ramaswamy A, Matthäi E, Chaloupka B, Gress TM, Langer P, Bartsch DK.
Transl Oncol 2013; 6:99-103.

MicroRNAs 196a and 196b as potential biomarkers for the early detection of familial pancreatic cancer.
Slater EP, Strauch K, Rospleszcz S, Ramaswamy A, Esposito I, Klöppel G, Matthäi E, Heeger K, Fendrich V, Langer P, Bartsch DK.
Ann Surg 2013; eingereicht.

Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
Bartsch DK, Dietzel K, Bargello M, Matthaei E, Klöppel G, Esposito I, Heverhagen JT, Gress TM, Slater EP, Langer P.
Fam Cancer 2013; 12:89-96.

Variation in Precursor Lesions of Pancreatic Cancer among High-Risk Groups.
Potjer TP, Schot I, Langer P, Heverhagen JT, Wasser MN, Slater EP, Klöppel G, Morreau HM, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bargello M, Gress TM, Vasen HF, Bartsch DK; on behalf of the Leiden Familial Pancreatic Cancer Group and the FaPaCa registry.
Clin Cancer Res. 2013; 19:442-449.

Familial pancreatic cancer- current knowledge
Bartsch DK, Gress TM, Langer P.
Nat Rev Gastroenterol Hepatol 2012; 9:445-453.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.
J Pathol 2012; 226:723-734.